1578Clinical Features, Vaccine Status and S. Pneumoniae Serotypes among HIV-positive and HIV-negative Individuals Diagnosed with Invasive Pneumococcal Disease
نویسندگان
چکیده
among HIV-positive and HIV-negative Individuals Diagnosed with Invasive Pneumococcal Disease Dharushana Muthulingam, MD, MS; Arnold Yee, MBA; Wendy Leyden, MPH; Michael Silverberg, PhD, MPH; Roger Baxter, MD; Internal Medicine, Kaiser Permanente Northern California, Oakland Medical Center, Oakland, CA; Kaiser Permanente Vaccine Study Center, Oakland, CA; Division of Research, Kaiser Permanente, Oakland, CA
منابع مشابه
Invasive pneumococcal disease: clinical features, serotypes, and antimicrobial resistance patterns in cases involving patients with and without human immunodeficiency virus infection.
We reviewed 153 episodes of invasive pneumococcal disease involving 147 hospitalized patients with and without human immunodeficiency virus (HIV) disease to examine and compare epidemiologic and clinical features, capsular serotypes, and antibiotic susceptibility patterns. HIV infection was the most common risk factor for invasive pneumococcal disease. Pneumococcal disease in HIV-infected indiv...
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OBJECTIVE HIV-infected adults have high rates of pneumococcal carriage and invasive disease. We investigated the effect of antiretroviral therapy (ART) on pneumococcal carriage in HIV-infected adults prior to infant pneumococcal conjugate vaccine (PCV) rollout. DESIGN Observational cohort study. METHODS We recruited HIV-infected adults newly attending a rural HIV clinic in northern Malawi b...
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BACKGROUND Streptococcus pneumoniae is a leading cause of pneumonia, meningitis and sepsis in developing countries, particularly among children and HIV-infected persons. Pneumococcal oropharyngeal (OP) or nasopharyngeal (NP) colonization is a precursor to development of invasive disease. New conjugate vaccines hold promise for reducing colonization and disease. METHODS Prior to introduction o...
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INTRODUCTION Streptococcus pneumoniae is the commonest cause of bacteremic pneumonia among HIV-infected persons. As more countries with high HIV prevalence are implementing infant pneumococcal conjugate vaccine (PCV) programs, we aimed to describe the baseline clinical characteristics of adult invasive pneumococcal disease (IPD) in the pre-PCV era in South Africa in order to interpret potential...
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BACKGROUND Newly diagnosed HIV-positive individuals are 35 to 100-fold more susceptible to Streptococcus pneumoniae infection compared to non-infected individuals. Therefore, the 23-valent pneumococcal polysaccharide vaccine (PPV23) has previously been recommended, though efficacy and effectiveness of vaccination remains controversial. Early severe B cell dysfunction is a central feature of HIV...
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